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E3 ubiquitin ligase Cbl-b potentiates the apoptotic action of arsenic trioxide by inhibiting the PI3KAkt pathway Yingchun Li, Xiujuan Qu, Jinglei Qu, Ye Zhang, Jing Liu, Yuee Teng, Xuejun Hu, Kezuo Hou and Yunpeng Liu

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Academic year: 2019

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Figure  3A).  After  treatment  with  ATO,  dose-dependent   inhibition  of  cell  growth  was  observed  in  RBL-2H3  cells  with an IC 50  at 24 h of 18.54 μM
Figure 2. Up-regulation of Cbl-b by arsenic trioxide. Total proteins  or  the  proteins  in  the  cytosolic  fractions  were  isolated  and  E3  ubiquitin ligase Cbl-b, phospho-Akt (p-Akt) and β-tubulin levels  were measured by Western blotting
Figure 4. Modulation of phospho-Akt (p-Akt) level by arsenic trioxide. A, Total proteins or the proteins in the cytosolic frac- frac-tions were isolated and p-Akt and Akt levels were measured by Western blotting

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