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Sustained spindle-assembly checkpoint response requires de novo transcription and translation of cyclin B1.

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Academic year: 2017

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Figure 3. Cyclin B1 and Securin are degraded during mitotic slippage induced by inhibition of transcription and translation
Figure 4. Expression of Mad1, Mad2, BubR1 and Cdc20 are not affected by inhibition of transcription, whereas Bub3 transcript levels are affected but Bub3 protein is not
Figure 5. Inhibition of transcription results in the decrease of Cyclin B1 mRNA levels, but do not affect Securin’s transcripts.

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