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Rational design, synthesis, and biological evaluation of heterocyclic quinolones targeting the respiratory chain of Mycobacterium tuberculosis

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Academic year: 2021

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Figure 2. Schematic representation of the respiratory chain of M. tuberculosis. The chain components are: Ndh/NdhA, type II NADH:(mena)quinone oxidoreductase (two isoforms); ETF, electron transferring fl avoprotein (transfer of reducing equivalents from fat
Figure 3. Identification of the quinolone template for lead optimization.
Table 1. Yields for the Synthesis of Compounds 1, 2, 7a − k
Table 2. Yields for the Synthesis of Compounds 14a − c and 15a − f
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