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Oral lactate intensifies insulin toxicity during severe insulin-induced hypoglycemia in mice

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Academic year: 2019

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FIGURE 1  - Dose response curve and seizures. Blood glucose levels at 0, 30, 60, 90, and 120 min after an intraperitoneal injection  (0.5, 1.0, 1.5, 2.0, 3.0, 4.0, 5.0 or 10.0 U/Kg) of insulin into 15 h fasted mice
TABLE II  -  Effect of oral glucose (5.5 mmol/kg) or lactate (18.0 mmol/kg) on seizures and deaths among hypoglycemic mice that  received intraperitoneal insulin (10.0 U/kg)
TABLE III  -  Effect of intraperitoneal (ip) diazepam (3.0 mg/kg) on seizures and the death rate among mice that received ip insulin  (10.0 U/kg) Seizure  rate Onset of first seizure (min) Number of seizures
FIGURE 3  - Scheme based on the model proposed by Pellerin and Magistretti (2012). Our hypothesis is that during severe  hypoglycemia, the availability of glucose to astrocytes becomes sharply decreased

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