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Hepcidin is regulated by promoter-associated histone acetylation and HDAC3

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Fig. 1 Effects of erythropoietin and iron de fi ciency in vivo. Effects of (1) 3 days erythropoietin (Epo) 200 IU i.p
Fig. 2 Effects of ID in Fam132b knockout mice. Effects of 3-week iron-de fi cient diet compared with control diet in 5-week-old wild-type and Fam132b knockout mice, on a liver iron content, b hepatic Hamp1 mRNA expression, c hepatic Bmp6 mRNA expression, d
Fig. 3 Chromatin modi fi cations at the hepcidin locus. a Diagram of hepcidin gene from UCSC genome browser, demonstrating ENCODE tracks for hepatic histone marks, DNase hypersensitivity (DNase-seq), and RNA expression (RNA-seq) in context and at the Hamp1
Fig. 4 Effects of Epo treatment or ID with PB co-administration. six- to eight-week-old C57Bl/6 male mice were treated with 200 IU Epo per day for 3 days with or without Panobinostat 0.4 mg (20 mg/kg) (a – c)
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