• Nenhum resultado encontrado

Proteasome-mediated proteolysis of SRSF5 splicing factor intriguingly co-occurs with SRSF5 mRNA upregulation during late erythroid differentiation.

N/A
N/A
Protected

Academic year: 2017

Share "Proteasome-mediated proteolysis of SRSF5 splicing factor intriguingly co-occurs with SRSF5 mRNA upregulation during late erythroid differentiation."

Copied!
17
0
0

Texto

Loading

Imagem

Figure 1. Opposite patterns of expression of SRSF5 mature mRNA and protein during late erythroid differentiation
Figure 2. SRSF5 expression in primary ex-vivo erythroid precursors. A. Flow cytometric analysis of proliferating (black line) and differentiating (grey line) cells
Figure 7. Phosphorylation by the CLKs or by AKT is not required for proteasome-mediated degradation of SRSF5
Figure 8. Functional analysis of SRSF5 on endogenous pre-mRNA splicing. To examine the impact of SRSF5 expression on splicing, we used 4.1R exon 16 as a model for endogenous erythroid splicing event.A
+2

Referências

Documentos relacionados

Of note, in this pathway set, there were 30 dysregulated pathways, such as mRNA splicing, mRNA splicing-major, RNA polymerase I, and DNA replication pathways, that owned a high

A partir da abordagem de autores contemporâneos como Hannah Arendt, John Rawls e Jür- gen Habermas, o texto pretende discutir a relevância da desobediência civil, en- quanto meio

CHAPTER 4: The Arabidopsis SR45 splicing factor, a negative regulator of sugar signaling, targets alternative splicing of the 5PTase13 gene and modulates SnRK1.1 levels

Endoplasmic reticulum stress- induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein response. Two regulatory

Os ligandos são normalmente ligados covalentemente a um suporte sólido, por exemplo agarose, sendo que os ligandos utilizados podem ser compostos de peso molecular

To investigate the effects of Scriptaid treatment on mRNA and protein expression during early embryonic development, the expression levels of development-related genes and proteins

This work presents a novel mechanism by which cytoplasmic viral RdRp inhibits cellular gene expression in the pre-mRNA splicing processing step, which would inhibit mRNA synthesis

Using K562 cells as a model, we found that overexpression of THAP11 suppressed hemin induced erythroid differentiation of K562 cells with fewer benzidine-positive cells and lower