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Molecular biology of human epidermal receptors, signaling pathways and targeted therapy against cancers : new evidences and old challenges

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Academic year: 2018

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FIGURE 2  - Activation of the cytoplasmic signaling pathways Ras/Raf/MEK/Erk1-2 and phosphatidylinositol 3-kinase (PI3-K/
FIGURE 5  - Mechanisms of action of the two classes of drugs against HER receptors that have reached clinical phases: monoclonal  antibodies (trastuzumab) and tyrosine kinase inhibitors (TKIs) (geitinib and lapatinib).

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