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Increased neuronal α-synuclein pathology associates with its accumulation in oligodendrocytes in mice modeling α-synucleinopathies.

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Academic year: 2017

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Figure 1. a -Syn secretion from MN9D neuronal cells positively correlates with its expression level and levels of soluble oligomers.
Figure 2. a -Syn secretion from MN9D dopaminergic cells is associated with PUFA-enhanced a -Syn oligomerization
Figure 4. Oli-neu and OLN-93 oligodendroglial cells take up a -Syn from their environment
Figure 7. Oligodendrocyte are affected in A53T a -Syn tg mouse brains. A. Total RNA was extracted from one mouse brain hemisphere (n = 4–5 brains) of ntg and A53T a-Syn and analyzed by real time-PCR with specific primers as indicated in methods
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