In silico analysis identifies a C3HC4-RING finger domain of a putative E3 ubiquitin-protein ligase located at the C-terminus of a polyglutamine-containing protein

Human Scribble (Vartul) Is Targeted for Ubiquitin- Mediated Degradation by the High-Risk Papillomavirus E6 Proteins and the E6AP Ubiquitin- Protein Ligase. A strategy for

HEK293T cells were cotransfected with expression vectors for FLAG-tagged Hoxa2 (FLAG-Hoxa2wt), FLAG-tagged Hoxa2 KQN-RAA (FLAG-Hoxa2KQN-RAA), FLAG-tagged Hoxa2 WM-AA

An accumulation of SUMO chains also causes the extreme genome instability and cell cycle phenotypes of fission yeast that lack the SUMO-targeted E3 ubiquitin ligase (STUbL) Slx8-Rfp1

These genetic and biochemical results suggest that the Rtt101 Mms22 E3 ligase counteracts a function of Mrc1 that is linked to the replicative helicase at stalled replication forks,

We have demonstrated here that TRIM21 is tyrosine phosphorylated only in this domain indicating a possible role for the tyrosine phosphorylation of TRIM21 regulating its ability to

A previous study of structural disorder in the human ubiquitin-proteasome system found evidence for disorder in E1, E2 and—to the greatest extent—E3 enzymes, and provided examples

HEK293T cells were transfected with indicated expression plasmids of RIG-I wild type, mutations and ubiquitin, Novel E3/Stimulator of RIG-I... facilitated the ubiquitination of

Recent- ly, GRAIL (the E3-ubiquitin ligase gene related to anergy in lymphocytes) was shown to be responsible for the Th2 hypore- sponsiveness in a mouse model of