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Silencing prion protein in MDA-MB-435 breast cancer cells leads to pleiotropic cellular responses to cytotoxic stimuli.

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Academic year: 2017

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Figure 1. Effects of PrP knockdown on cell proliferation and colony formation. Levels of PrP expression in control siLuc cells (siLuc) and PrP knockdown cells (siPrP) was determined by immunoblot (A) and immunofluorescence analyses (B)
Figure 2. Responses of siPrP and siLuc cells to different cytotoxic stimuli. Cells were subjected to serum deprivation for 5 days (A), or incubated with doxorubicin (B), paclitaxel (C), or staurosporine (D) for 48 hours
Figure 3. The influence of PrP knockdown on serum deprivation and doxorubicin-induced cytotoxicity
Figure 5. PrP expression level and endogenous fluorescence of doxorubicin during and after doxorubicin treatment
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