A neuron-specific deletion of the microRNA-processing enzyme DICER induces severe but transient obesity in mice.

elegans , miRNAs are processed from premature form into mature form by alg-1/alg-2 (encoding the Argonaute proteins) and dcr-1 (encoding the ribonuclease III enzyme Dicer) [28].

Figure 1. Generation of a germ cell-specific Dicer1 knockout mouse line. A) Expression of Dicer1 mRNA as analyzed by RT-PCR on total testis RNA extracted from different time

SMC-specific knockout of Dicer prevented SMC miRNA biogenesis, causing dramatic changes in phenotype, function, and global gene expression in SMCs: the mutant mice developed

To examine the role of TRAF6 in Tregs, we generated Treg- specific TRAF6-cKO mice by using Foxp3 Cre-YFP knock-in mice.. This knock-in mouse harbors a cassette containing an

The inability of MKC4485 to reduce cell death in HCT116 cells indicates IRE1 RNase activity does not contribute to the observed protection despite DICER compromised cells

Sequences coding for proteins centrally involved in the miRNA pathway, namely DROSHA, DGCR8, XPO5, RAN, DICER, TARBP2, AGO and PIWI, have been methodically identified in the genomes

Tcf21 iCre/+ , Ldlr -/- mice were administered tamoxifen to activate expression of an inducible MerCreMer construct knocked into the Tcf21 locus to produce recombination and

Male and female Kiss1-Cre LepR lox/lox mice showed normal sexual maturation, fertility and fecundity, suggesting that leptin action in Kiss1 neurons is not necessary for puberty