HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity.

These genetic and biochemical results suggest that the Rtt101 Mms22 E3 ligase counteracts a function of Mrc1 that is linked to the replicative helicase at stalled replication forks,

We have demonstrated here that TRIM21 is tyrosine phosphorylated only in this domain indicating a possible role for the tyrosine phosphorylation of TRIM21 regulating its ability to

To identify if the kinase activity of Plk1 is involved in the interaction, FLAG-tagged Plk1 and the kinase-defective mutant FLAG-tagged Plk1 KD were expressed in β9γT

Recent- ly, GRAIL (the E3-ubiquitin ligase gene related to anergy in lymphocytes) was shown to be responsible for the Th2 hypore- sponsiveness in a mouse model of

A previous study of structural disorder in the human ubiquitin-proteasome system found evidence for disorder in E1, E2 and—to the greatest extent—E3 enzymes, and provided examples

Cells expressing Cul4b null allele in Cul4b heterozygous mice were selected against, to different degrees in different tissues, from early embryogenesis to early postnatal

Taken together, our data demonstrate that cIAP1 and cIAP2 are direct E3 ubiquitin ligases for all four RIPs and indicate that cIAP1 conjugates RIP1–4 with diverse types of

HEK293T cells were transfected with indicated expression plasmids of RIG-I wild type, mutations and ubiquitin, Novel E3/Stimulator of RIG-I... facilitated the ubiquitination of