Metformin reduces hepatic expression of SIRT3, the mitochondrial deacetylase controlling energy metabolism.

The beneficial effect of metformin was not limited to cisplatin- induced mechanical allodynia; also paclitaxel-induced mechanical allodynia was prevented by administration of

A study realized on polycystic ovarian syndrome patients, which compared the effect of metformin to those of the association metformin + NAC for short times (5 days), showed NAC

In the present work, metformin HCl and glimepiride, the two well-known anti- diabetic drugs, have been evaluated directly by transmission FTIR in dosage form by preparing

A rare but serious condition termed metformin-associated lactic acidosis (MALA) can develop in patients with predispos- ing factors such as renal impairment, hepatic disease,

Activation of AMPK by AICAR or metformin has an inhibitory effect on CFTR and may therefore abrogate the CTX induced hypersecretion of

Figure 5. Summary model of metformin action on C. Metformin activates SKN-1 to trigger DR-like metabolism and intestinal anti-oxidant gene expression. SKN-1 is needed in both the

These results suggest that PGC-1 b plays dual roles in regulating hepatic fatty acid metabolism by controlling the expression of programs of genes involved in both fatty acid

(A) Primary neurons were treated with increasing concentrations of metformin for 24 hours and BACE1 protein levels were analyzed on western blots using BACE1-, TACE- or