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The Pro allele of the p53 codon 72 polymorphism is associated with decreased intratumoral expression of BAX and p21, and increased breast cancer risk.

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Academic year: 2017

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Table 1. Clinical characteristics of the study population, and frequency of the TP53 Arg72Pro genotypes in the indicated subpopulations.
Figure 1. Age at breast cancer onset by Arg72Pro genotypes. Boxplots (A–C) and curves of the cumulative breast cancer incidence at the indicated age at onset (D–F) are shown for unselected patients (A, D), patients with p53 negative tumors (B, E), and pati
Figure 3. Kaplan-Meier analyses of the overall and disease-free survival. Overall survival (A–C) and disease-free survival (D–F) of patients with the Arg/Arg genotype and of Pro-allele carriers was compared
Table 5. Univariable and multivariable analyses of the disease-free survival using a Cox proportional hazards model.

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