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Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling

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Figure 1.  Increased phosphate concentrations induce calcification of mVSMCs in vitro
Figure 3.  Ucma/GRP expression is increased in calcifying mVSMCs. Cells were incubated in growth medium  (CM) or osteogenic medium (OM) containing 2.6 mM phosphate
Figure 4.  mVSMCs from Ucma/GRP −/−  mice show increased calcification. Cells from Ucma/GRP −/−  mice and  WT counterparts were incubated with growth medium (CM) or osteogenic medium (OM) containing 2.6 mM  phosphate
Figure 6.  Ucma/GRP is involved in suppressing osteo/chondrogenic differentiation by interacting with BMP-2
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