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The secondary alcohol and aglycone metabolites of doxorubicin alter metabolism of human erythrocytes

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Figure 1. Chemical structures of doxorubicin (DOX), doxorubicinol (DOXol), aglycone-DOX (agly-DOX) and aglycone-DOXol (agly-DOXol).
Figure 2. DOX, DOXol, agly-DOX and agly-DOXol stimulate the pentose phosphate pathway (PPP) in human red blood cells.
Table 1 reports the change in P 50  for Hb induced by DOX, DOXol, DOX and  agly-DOXol at pH 7.4 and 37ºC
Table 1. Oxygen affinity of hemoglobin A in the absence and in the presence of doxorubicin (DOX), doxorubicinol (DOXol), aglycone-DOX (agly-DOX) and aglycone-DOXol (agly-DOXol).

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