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Histone deacetylases play a major role in the transcriptional regulation of the Plasmodium falciparum life cycle.

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Academic year: 2017

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Figure 3. Genome-wide histone hyperacetylation induced by apicidin. A. Chromosomal display of genetic loci, represented by MOEs, that showed a significant increase in H4K8Ac in apicidin treated trophozoites (D = 1.7) and schizonts (D = 5)
Figure 4. Apicidin induces histone hyperacetylation along promoter regions and protein expression of P
Table 1. Association between the genetic loci with altered histone modifications and genes induced by apicidin.
Figure 5. Inhibition of HDACs induces expression of transcription associated proteins

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