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The translocator protein (Da) and its role in disorders

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Fig. 1. MPTP functions in the apoptosis pathway. Cardiolipin can be oxidized by ROS, which triggers the release of cytochrome-c, allowing cytochrome-c to enter the cytosol and induce apoptosis
Fig. 3. Effects of ROS on MPTP. Mitochondrial ROS induced the ac- ac-tivation of protein kinase-C ε (PKC ε ) through the MAPK/ERK-1/2 pathway, which is also known as the Raf-1-MEK1/2-ERK1/2 pathway.

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