• Nenhum resultado encontrado

MET Gene Amplification and MET Receptor Activation Are Not Sufficient to Predict Efficacy of Combined MET and EGFR Inhibitors in EGFR TKI-Resistant NSCLC Cells.

N/A
N/A
Protected

Academic year: 2017

Share "MET Gene Amplification and MET Receptor Activation Are Not Sufficient to Predict Efficacy of Combined MET and EGFR Inhibitors in EGFR TKI-Resistant NSCLC Cells."

Copied!
22
0
0

Texto

Loading

Imagem

Fig 1. Cell inhibition growth analysis of ERL-resistant NSCLC cell lines. A) Representative dose-effect curve plots of HCC827 and HCC4006 parental cell lines to the indicated TKIs
Fig 2. The ERL-resistant HCC827 cells lines are tumorigenic. A) Soft agar colonies were counted by ImageJ software
Fig 3. Analysis of the EGFR gene in the RA2 ERL-resistant cell line. A) Analysis of EGFR exon 19 nucleotides sequence
Fig 4. Erlotinib impairs EGFR and ERK1/2 phosphorylation in ERL-resistant cell lines. A) Representative western blots with EGFR and ERK1/2 antibodies and B) pEGFR (Y1068) and pERK1/2 (T202/Y204) antibodies in the indicated parental and ERL-resistant cell l
+7

Referências

Documentos relacionados

AKT: protein kinase B, EGFR: epidermal growth factor recep- tor, FGFR: fibroblast growth factor receptor, IGF-1R: insulin growth factor 1 receptor, MET: hepatocyte growth

cancer for epidermal growth factor receptor and anaplastic lymphoma kinase tyrosine kinase inhibitors: American Society of Clinical Oncology Endorsement of the College of

American Society of Clinical Oncology provisional clinical opinion: epidermal growth factor receptor (EGFR) Mutation testing for patients with advanced non-small-cell lung

The model validation was performed comparing the results of modal numerical analysis with the in situ measurements, for which a set of dynamic tests was carried out in order

Neste sentido foi proposto um modelo que permitisse explicitar esta relação, bem como identificar e explicar a forma como a qualidade de vida e a comunicação da marca

NA obra de Verdi a voz está mais isolada porque o acompanhamento é mais simples e meramente sustentador, no entanto na obra de Puccini, a orquestra ao tocar

The aim of this study was to evaluate the frequency of epidermal growth factor receptor and KRAS mutations in a population of Brazilian patients with non-small cell lung

Do conjunto de críticos vindos das gerações anteriores, Fernando Pernes, ainda que nunca se debruçando em concreto sobre o trabalho de Sarmento destes anos nos textos