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Lef1 haploinsufficient mice display a low turnover and low bone mass phenotype in a gender- and age-specific manner.

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Academic year: 2017

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Figure 1. Low trabecular bone mass in Lef1 +/2 female mice. (A,C) mCT analysis of the distal femoral (A) and the vertebral (C) trabecular bone of Lef1 +/+ (black) and Lef1 +/2 (white) female (left) and male (right) 13-week old mice
Figure 2. Low bone formation in Lef1 +/2 female mice. Histomor- Histomor-phometric analysis of the distal femoral metaphysis from Lef1 +/+ (black) and Lef1 +/2 (white) female (left) and male (right) 17-week old mice
Figure 5. Androgen signaling protects against Lef1 haploinsufficiency-induced low bone mass
Figure S1 Lef1 2 / 2 mice have normal bone development.

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