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CREB targets define the gene expression signature of malignancies having reduced levels of the tumor suppressor tristetraprolin.

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Academic year: 2017

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Fig. 1. Differentially expressed genes between tumors in TCGA datasets with high and low expression of TTP
Fig. 2. Identification of the TTP -low tumor gene signature. Venn diagram showing the overlap of differentially expressed genes between TTP-high and TTP-low expressing tumors
Table 1. AREs located in genes in the TTP-low tumor gene signature. Gene Symbol ARE in3 9 UTR a ARE Nonamers(UUAUUUAUU) a ARE Octamers(UAUUUAUU)a ARE Heptamers(UAUUUAU)a ARE Pentamers(AUUUA)a ADAMTS1 Yes 0 1 0 3 ADAMTS8 Yes 0 0 0 1 ADH1B Yes 0 0 0 7 AG2 Ye
Table 1. Cont. Gene Symbol ARE in3 9 UTR a ARE Nonamers(UUAUUUAUU) a ARE Octamers(UAUUUAUU)a ARE Heptamers(UAUUUAU)a ARE Pentamers(AUUUA)a SIK1 Yes 0 0 0 3 SLC6A14 Yes 1 0 0 7 SLIT3 Yes 0 0 0 1 SOCS3 Yes 0 0 2 2 TPSB2 No 0 0 0 0 TTP (ZFP36) Yes 1 0 0 4 VSI
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