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Aplicação terapêutica de células endoteliais tratadas com nanopartículas contendo ácido retinóico em modelo experimental de acidente vascular cerebral

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Table 1. Number (n) and percentage of deaths (%) from cerebrovascular disease in Europe by sex and  age (adapted from(2)).
Figure 1. Different types of stroke. Ischemic stroke occurs when a blood clot stops blood flow to a region  of  the  brain,  while  hemorrhagic  stroke  occurs  when  blood  leaks  into  the  brain  parenchyma  (adapted  from(7))
Figure  2. Schematic  representation  of  the  components  of  the  neurovascular  unit
Figure 3. RA signaling pathway depicting generation, action and catabolism of RA. (CRABP2 -  cellular  retinoic-acid-binding  protein  2;  CYP26  -  retinoic  acid-inactivating  enzyme;  RA  –  retinoic  acid;  Ral  –  retinaldehyde;  RALDHs  -    retinald
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