Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models

US: ultrasonography; MRI: magnetic resonance imaging; EEG: electroencephalogram; AIS: arterial ischemic stroke; MCA: middle cerebral artery; CSVT: cerebral sinus venous

130 reported its neuroprotective effect in a model of focal ischemia with 70% xenon administration during ischemia induced by cerebral artery occlusion in rats and showed a

A brain CT was performed which showed severe cerebral hemispheric ischemia with signs of fat emboli in right middle cerebral artery; transesophageal echocardiog- raphy showed a

Arteriogra- phy confirmed occlusion of the right popliteal artery (Figure 1C) with collateral circulation and a functional angiogram in active flexion of the left limb revealed

This resembles the effect of other manipulations that block Notch signaling totally [5,6,8], and it confirms that Dll1 and Dll4, expressed in the same cells and acting in parallel

In this way, re- tarded growth of autochthonous skin tumors under the condition of increased endothelial Dll4/Notch signaling was demonstrated to be a consequence of reduced

Reduced trabecular thickness and BV/TV also were seen in male Akt2-deficient mice and their wild-type littermates compared with male wild-type mice from comparable Akt1-

Skeletal and cardiac muscle fibrosis were also significantly increased in untreated mdx mice compared to wild type, but there was no significant improvement in treated mdx mice..