A Higher Activation Threshold of Memory CD8+ T Cells Has a Fitness Cost That Is Modified by TCR Affinity during Tuberculosis.

However, infants who were breastfed until 3 months had higher CD8 T-cell numbers than infants who were never breastfed, and this change persisted when breastfeeding was prolonged

The curves of parasitemia observed in WT C57BL/6 or CD8 KO mice challenged with different parasite doses, strongly suggest that protective CD8 + T cells are important for mouse

An evaluation of the cytotoxic activity of CD8+ T cells in sub-clinical infections and patients with CL showed that CD8+ T cells in individu- als with CL induced apoptosis of

Thus, HVEM expressed on a CD8 T cell is required for survival of effector T cells and formation of a large population of cytokine- competent memory cells during infection with

The relative number of CD8 T cells were analyzed by calculating the ratio between the numbers of CD8 T cells and Monoclonal B Clone (MBC) (T/NK cells: MBC ratio) as previously

Conversely, tetramer-specific CD8 T-cells from TB patients contained higher proportions of cells with an effector memory-like (15% in TB patients versus 5% in LTBI subjects) and

memory cells in a multi-ethnic population and demonstrated that the degree of chronic adaptive immune activation, as estimated by lower circulating naive cells and higher memory

Our data indicate that while the development of single positive CD4 + and CD8 + T cells in the thymus remained intact in granzyme B-deficient mice, the peripheral pool of CD8 + T