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Matriptase autoactivation is tightly regulated by the cellular chemical environments.

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Figure 4. Chloride ions but not sodium ions suppress matriptase zymogen activation. Living 184 A1N4 mammary epithelial cells were exposed to pH 6.0 phosphate buffers containing increasing concentrations of the indicated salts at room temperature for 20 min
Figure 7. Knockdown of matriptase expression increases susceptibility to CdCl 2 toxicity

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