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NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches.

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Academic year: 2017

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Table 1. Patient characteristics.
Figure 3. hN1 mAb treatment inhibits NOTCH1-driven LIC self-renewal. (A) Graph depicting average number of caspase 3 (red) and NOTCH1 (blue) positive cells (mean 6 SEM), measured by marrow immunohistochemistry (cell number/randomized 406fields) following h
Figure 4. hN1 mAb treatment inhibits NOTCH1 Mutated LIC burden. (A) Comparative FACS analysis of human CD34 + CD45 + cells and CD34 + CD2 + leukemic burden in the bone marrows from NOTCH1 Mutated LIC (Patient 11) engrafted mice following treatment with con
Figure 5. An expanded CD45 + CD34 + CD2 + CD7 + population in NOTCH1 Mutated T-ALL LIC is sensitive to hN1 mAb treatment
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