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Involvement of DNA-PKcs in the type I IFN response to CpG-ODNs in conventional dendritic cells in TLR9-dependent or -independent manners.

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Academic year: 2017

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Fig 1. DNA-PKcs but not Ku70 is involved in the type I IFN response to CpG-ODNs. Bone marrow was isolated from WT, DNA-PKcs -/- , TLR9 -/- and Ku70 -/- mice and then cultured with GM-CSF for 7 days
Fig 2. Both DNA-PKcs and TLR9 are important for the IFNα response to CpG-A, and rapamycin diminishes this response
Fig 3. The type I IFNs are involved in the IL-6 and IL-12 responses to CpG-ODNs in DNA-PKcs-deficient DCs
Fig 4. DNA-PKcs and TLR9 are important for phosphorylation of the Akt/mTORC1 pathway, IKKα, IRAK1, ERK and Stat1 in response to CpG-ODN.
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