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The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.

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Academic year: 2017

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Figure 2. Effect of SIRT1 overexpression on intestinal tumor formation and proliferation in Apc min/+ mice
Figure 3. SIRT1 inhibits b-catenin driven cell proliferation and transcriptional activity
Figure 4. SIRT1 represses b-catenin transcriptional activity by directly interacting with and deacetylating b-catenin
Figure 5. SIRT1 expression occurs in a subset of human colon cancers and inversely correlates with the nuclear localization of b-catenin

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