Caracterização da actividade laboratorial a nível nacional Área de Endocrinologia

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Caracterização da actividade laboratorial a nível

nacional

Área de Endocrinologia

GRUPO DE ESTUDOS DE LABORATÓRIO-SPEDM

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GRUPO DE ESTUDOS DE LABORATÓRIO-SPEDM 2 R es p o n sá vel LE N D D rª D eo lin d a M ad u rei ra D r N u n o G o n ça lv es D r N u n o C u n h a D rª H el en a P ro en ça D rª C o n cei çã o G o d in h o D rª Is ab el G ri ff D rª A n a D ia s/ D rª L El ia s D rª M ª Is ab el C ar va lh o D rª J o ão Fer m is so n D rª J . D u ar te /D rª Is ab el S an to s D rª F . Lei tã o D rª Is ab el A lb u q u er q u e D r Fr ed er ic o C er vei ra D rª S . Si lv a/ D rª I . C aeta n o D r Jo sé G o n za lez D rª A n ab el a Si lv a D r Jo sé C ar lo s O liv ei ra P ro f Ti ag o G u im ar ães D r M an u el Si lv a D r Jo sé P ed ro so Dr Ili d io O rn el as D r R ic ar d o C as tr o

Centro Hospi talar ---- --- --- CHLN CHLC CHLO ---- CHBM CHS CHUC CHBV ---- ---- ---- CHP CHSJ ---- CHVNG ---- CHLP Anali to

Hospi tal IPOL IPOP IPOC HSM HCC HDE/

HSJ SF

Xa vier HGO Ba rrei ro HSB HUC CHC HAvei ro HLA ULSAM CHPVVC HGSA HSJoão HML --- HCF HSA

ACTH I R I I I I I I R R I I ---- ---- I R ---- I R R 5-HIAA Cr/E HPLC Cr/E HPLC HPLC 2-G ---- --- ---- ---- 2-? ---- ---- ---- HPLC HPLC ---- --- HPLC --- Ác. Vanilmandélico (AVM) Cr/E HPLC Cr/E HPLC HPLC 2-G ---- --- --- ---- 2-? ---- ---- ---- HPLC HPLC ---- Cr/E HPLC Cr/E Aldosterona (soro/urina) 1-Dias ---- 1-Dsl 1-Siemc 1-Siem 1-B 1 1-Siem ---- L 1-DSL ---- ---- ---- 1-Siem 1-Siem ---- 1-Siemc

2-?a --- Ac Anti- Tg e Anti-TPO U R I I I Ac I R R Ar I Ct ---- R R Ar I R Ac U TRAb 1-RSR R R R 1-Brah 1-M 1-? R ---- R 1-Brah ---- ---- --- R 2-Euri ---- 1-RSR R --- Actividade Renina Plasmática 1-Dias ---- L ---- ---- ---- ---- ---- ---- L L ---- ---- ---- --- --- ---- 2-Dia ---- --- β hCG Livre ---- ---- ---- I ---- I K ---- --- ---- K I ---- R R Def ---- --- K K hCGTotal I R I I I Ac D R R Ar I D ---- ---- I R I R Ac Ac Calcitonina I I I I I I I I ---- ---- I ---- ---- ---- I I ---- I ---- --- Catecolaminas plasmáticas --- --- --- --- --- --- --- --- --- --- --- --- --- --- HPLC HPLC --- --- --- --- Catecolaminas na urina ---- HPLC ---- HPLC HPLC 2-G ---- ---- ---- ---- 2-? ---- ---- ---- HPLC HPLC ---- ---- HPLCa --- Cortisol (soro) 1-Siem R R Ct I Ac I R R Ar I Ct ---- R R R I R Ac Ac Cortisol (urina) 1-Siem ---- R ---- 1-Siem ---- 1-? R ---- ---- 1- Siem ---- ---- ---- R R --- 1-Dia ---- Ac Cortisol (saliva) 1-Dias R R Ct 1-Dias --- --- R --- --- --- --- --- ---- R R --- --- ---- --- Cromogranina A 1-CIS 1-Eur K 1-Eur --- --- 1-? --- --- --- 1- Eur --- --- ---- 2-EDI --- --- --- ---- --- DHEA-SO4 (DHEA-S) I I I I I Ac I R R R I --- --- R I R --- R Ac --- Delta-4 Androstenediona I I I I I I I I --- --- I ---- --- ---- I I --- 1-Dias 2-?a --- DHT 1-Bec --- --- --- --- 1-Bec --- --- --- --- --- --- --- ---- 1-Bec --- --- --- --- --- 11-Desoxicortisol --- --- --- 1-Bio --- 1-MP --- --- --- --- 1-Dia --- --- ---- 1-IBL --- --- --- --- --- Desoxipiridinolina (DPD) I --- --- I --- I I --- --- --- I --- --- ---- I --- --- --- --- --- Estradiol (17 β estradiol) I I Ct Ct I Ac V R R R Ct Ct Ac R R R I R Ac Ac

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GRUPO DE ESTUDOS DE LABORATÓRIO-SPEDM 3

Anali to IPOL IPOP IPOC HSM HCC HDE SF

Xa vier HGO Ba rrei ro HSB HUC CHC HAvei ro HLA ULSAM CHPVVC HGSA HSJoão HML CHVNG HCF HSA

FSH I R Ct Ct I Ac V R R R Ct Ct Ac R R R I R Ac Ac Gastrina I I I I --- --- --- --- --- --- I I --- ---- I --- --- 1-Dia --- --- Glucagon --- --- --- --- --- --- --- --- --- --- 1-? --- --- --- --- --- --- 1-MP --- --- HbA1c --- HPLC --- HPLC HPLC HPLC HPLC HPLC HPLC HPLC HPLC HPLC HPLC HPLC HPLC HPLC HPLC HPLC HPLC CAP 17α-Hidroxi-Progesterona 1-Siem 1-Siem 1-Siem 1-Siem 1-Siem 1-Bec 1-? 1-Siem --- --- 1-Dia --- --- --- 1-? 1-Siem --- 1-Siem 2-?a Ac 17- Hidroxicorticosteróides Q/E --- --- ---- --- --- --- --- --- --- --- --- --- --- --- --- --- ---- Cl/Ea ---

Hormona do Crescimento I I I I I Ac I I --- --- I --- --- --- I I --- I Ac --- Hormona Anti-diurética --- --- --- 1-Eur --- --- --- --- --- --- --- ---- ---- ---- 1-? --- ---- 1-Dia ---- --- IGF1 (Somatomedina C) I I I I I I I 1-Med ---- ---- I ---- ---- --- I 1-Im ---- 1-Med 2-?a _---

IGFBP3 ---- ---- I I I I ---- ---- ---- ---- I --- ---- ---- I I ---- 1-Med ---- --- Insulina I I R Ct I Ac I I R R Ct Ct ---- R R R I R Ac Ac Iodo Urinário Col ---- Col ---- ---- ---- ---- --- ---- ---- ---- --- ---- ---- Col --- ---- ---- ---- --- LH I R Ct Ct I Ac V R R R Ct Ct Ac R R R I R Ac Ac Macroprolactina (identificação) PEG ---- K ---- PEG ---- ---- ---- ---- ---- --- --- ---- ---- ---- --- ---- PEGa _PEG _---

Metanefrinas plasmáticas --- --- 1-LDN --- --- --- --- --- --- --- --- --- --- --- 1-LDN --- --- --- --- --- Metanefrinas urinárias Cr/Ea _HPLC _{1-LDN HPLC} _HPLC _2-G _1-? _---- _---- _---- _2-? _--- _---- _---- _HPLC _HPLC _---- _Cr/E _HPLCa_Cr/E

Normetanefrinas plasmáticas --- --- 1-LDN --- --- --- --- --- --- --- --- --- --- --- 1-LDN --- --- --- --- --- Normetanefrinas urinárias --- HPLC 1-? HPLC HPLC 2-G 1-? ---- ---- ---- 2-? --- ---- ---- HPLC HPLC ---- ---- HPLCa_--- Osteocalcina --- ---- R R ---- I ---- ---- ---- ---- --- --- ---- ---- R R ---- ---- R --- Parathormona (PTH) I R Ct Ct I Ac V R ---- Ar Ct Ct Ac R R R I R Ac --- PTH intra-operatória I R Ct Ct ---- ---- Ac ---- ---- Ar Ct --- Ac R R R I ---- Ac --- Peptido C (soro/urina) I I R Ct I I I Ic _R _R _I _Ct _---- _Rc _Rc _R _---- _R _R _--- Progesterona I I Ct Ct I Ac V R R R Ct Ct ---- R I R I R Ac Ac Prolactina (PRL) 1-Dia R I Ct I Ac V R R R Ct Ct ---- R R R I R Ac Ac RBP (Retinol B. Protein) ---- ---- ---- NEF ---- ---- ---- --- ---- ---- --- --- ---- --- NEF NEF ---- ---- ---- --- Renina --- ---- ---- 1-? L 1-Bec 1-RIA 1-Dia ---- L --- --- ---- --- 1-Dia 1-Cis ---- 1-Dias 2-?a --- Serotonina ---- ---- 1-DRG HPLC ---- 2-G ---- ---- ---- ---- 2-? --- ---- --- HPLC --- ---- ---- ---- --- SHBG --- ---- I I I Ac ---- ---- ---- ---- ---- --- ---- --- I R ---- R Ac ---

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Triiodotironina (T3) R R R Ct I ---- ---- R R Ar --- Ct Ac R R Ar I R Ac Ac Tiroxina (T4) R R R Ct I ---- ---- R R ---- ---- Ct Ac R R Ar I R Ac Ac T3 Livre (FT3) R R R Ct I Ac V R R ---- Ct Ct Ac R R Ar I R Ac Ac T4 Livre (FT4) R R R Ct I Ac V/D R R Ar I Ct Ac R R Ar I R Ac Ac Testosterona Livre 1-Siem 1-Bec 1-DSL 1-Siem 1-Siem 1-Bec ---- 1-Siem ---- ---- 1-Siem ---- ---- ---- 1-Siem 1-Siem ---- 1-Siem b --- Testosterona Total I R R I 1-Siem 1-O I R R R Ct Ct --- R R R ---- R Ac Ac Tireotrofina (TSH) R R I Ct I Ac V/D R R Ar Ct Ct Ac R R Ar ---- R Ac Ac Tiroglobulina (TG) I R I I I Ac I R --- R I I --- R R I ---- R R Ac Vitamina D (1,25 OH) 1-IDS ---- ---- --- ---- 1-IDS ---- --- --- ---- --- ---- --- ---- ---- --- ---- ---- ---- --- Vitamina D (25 OH) 1-IDS ---- R Ar L 1-IDS Ar R ---- R L Ct --- ---- R R ---- R R --- VIP ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- 1-? ---- ---- ---- 1-Eur --- ---- ---- --- EPO I ---- i ---- ---- ---- I ---- ---- ---- ---- ---- ---- ---- I I ---- I ---- ---

*Metanefrinas Totais (metanefri nas+normeta nefrinas )

Equipamento Método Reagentes

Ar Architect 1 RIA/IRMA B Immunotech/Beckman Coulter Ac Access, DXi600, DXi800 2 ELISA Bec Beckman

Cap Capilarys 2 Flex Piercing - Sebia NEF Neflometria Bio Biosource Ct Advia Centaur Cr/E Cromatográfico/Espectrofotométrico Brah Brahms D Dimension Vista Col Colorimétrico CIS CisBio Def Delfia Q/E Químico/ Espectrofotométrico Dia DiaSource K Kriptor PEG Precipitação c/PEG Dias Diasorin I Immulite, Immulite 2000/Immulite 2500 Cl/E Cromatografia líquida/ Espectrofotométrico DRG DRG

L Liasion DSL DSL

K Kriptor EDI Epitope Diagnostics R Cobas e411/e601, Modular E170, Cobas Integra Eur Eurodiagnostica U Unicap Euri Euroimmune V Vitros Eci G Grifols

a_{-em instalação} _IBL _IBL b

-por cálculo LDN Labor Diagnostika Nord

c_-soro _M _Medipan Med Mediagnostic MP MP Biomedicals O Orion RSR RSR Siem Siemens/DPC

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Alfa-subunidada da HCG --- --- --- --- --- --- --- ---- --- --- ---- ---- --- ---- 1-Im --- ---- --- --- --- 3 Alfa-Androstenadiol --- --- --- --- --- --- --- --- --- --- --- --- --- --- 1-DSL --- --- --- --- --- Ac Anti-Insulina --- --- --- --- 1-RSR --- --- --- --- --- --- --- --- --- 1-RSR 1-DLD --- 1-Dias --- --- Ac anti-células Langerhans (ICA) --- --- --- --- --- --- --- --- --- --- --- --- --- --- 2-Bio --- --- --- --- --- Ac Anti-GAD --- --- --- --- 1-RSR --- --- --- --- --- --- --- --- --- 1-Med 1-DLD --- --- --- --- Ácido Homovanílico --- --- --- --- --- --- --- --- --- --- --- --- --- --- HPLC HPLC --- --- --- --- Beta-Crosslaps (B-CTX) --- --- R --- --- --- --- --- --- --- --- --- --- --- R R --- --- --- --- Elastase Pancreática fecal --- --- --- --- --- --- --- --- --- --- --- --- --- --- 2-Sc --- --- --- --- --- Estriol livre --- --- --- I --- I --- --- --- --- I I --- --- I I --- --- Ac --- Estrona --- --- 1-DSL ---- --- --- --- --- --- --- --- --- --- --- ---- --- --- --- --- --- Fosfatase Alcalina óssea 1-Q --- l --- --- --- --- --- --- --- --- --- ---- ---- 2-Q --- --- --- --- --- Homocisteína ---- --- --- --- --- --- --- --- --- --- --- --- --- --- I Ar --- --- --- Ax Leptina --- --- --- --- --- --- --- --- --- --- --- --- --- --- 2-Mer --- --- --- --- --- Procolagénio I --- --- --- --- --- --- --- --- --- --- --- --- --- --- R --- --- --- --- --- Procolagénio III --- --- --- --- --- --- --- --- --- --- --- --- --- --- 1-O --- --- --- --- --- TBG --- --- --- --- --- ---- --- --- --- --- --- --- --- --- ---- --- --- --- --- --- Ac anti IA2 --- --- --- --- 1-RSR --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

Equipamento Método Reagentes

Ac Access, DXi 600, DXi 800 1 RIA/IRMA Bi o Bi ometri ca

I Immulite, Immuli te 2000/Immulite 2500 2 ELISA DSL DSL

R Cobas e411/e601, Modula r E170, Cobas Integra DLD DLD

Im Immunotech Q Quidel Mer Mercodia Med Medipan O Orion RSR RSR Sc Schebo Ax Axis-Shield Beckman AU 2700