Dissertation submitted in Faculdade de Ciências e Tecnologia of
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![Figure 2.4: Representation of a dissected brain showing the precentral knob (indicated by arrows), which can look like an inverted omega (A) or a horizontal epsilon (B) when cut axially, and like a hook when cut sagittaly (C) [10]](https://thumb-eu.123doks.com/thumbv2/123dok_br/16535722.736522/30.892.89.766.81.385/figure-representation-dissected-precentral-indicated-inverted-horizontal-sagittaly.webp)
![Figure 2.5: Schematic diagram of the main steps of cerebral energetic metabolism (adapted from [1])](https://thumb-eu.123doks.com/thumbv2/123dok_br/16535722.736522/31.892.286.655.85.374/figure-schematic-diagram-steps-cerebral-energetic-metabolism-adapted.webp)
![Figure 2.7: The meaning of perfusion (adapted from [1]). (a) Illustration of blood vessels within a small element tissue for cerebral blood flow definition](https://thumb-eu.123doks.com/thumbv2/123dok_br/16535722.736522/32.892.97.765.787.1059/figure-meaning-perfusion-adapted-illustration-vessels-cerebral-definition.webp)
![Figure 3.1: Different image contrasts [19]. From left to right: T 1 -weighted, proton density-weighted and T 2 -weighted images](https://thumb-eu.123doks.com/thumbv2/123dok_br/16535722.736522/38.892.86.773.961.1133/figure-different-contrasts-weighted-proton-density-weighted-weighted.webp)
![Figure 3.9: Vascular architecture showing the different vessel types that could pass through a typical tissue volume [6]](https://thumb-eu.123doks.com/thumbv2/123dok_br/16535722.736522/47.892.228.689.88.413/figure-vascular-architecture-showing-different-vessel-typical-tissue.webp)
![Figure 4.3: Pulse sequence used for Q2TIPS ASL imaging. On the right the locations of the in-plane pre-saturation slab, imaging slice(s), periodic saturation slice, and inversion slab used in the PICORE labelling scheme are shown [38]](https://thumb-eu.123doks.com/thumbv2/123dok_br/16535722.736522/53.892.134.799.93.387/figure-sequence-locations-saturation-periodic-saturation-inversion-labelling.webp)
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