GFAP-Cre-mediated transgenic activation of Bmi1 results in pituitary tumors.

Our objective was to determine the effect of IFN- g on transgene expression driven by viral SV40 or CMV promoter/enhancer and the mammalian promoter/enhancer for the

To analyse whether split-Cre complementation induces recombination activity in vivo , we generated transgenic mice expressing NCre and CCre under the control of the mouse

Research in cognitive neuroscience has shown that excessive activation of the mammalian target of rapamycin complex 1 (mTORC1) pathway in transgenic rodents is associated

(2012) The Murine Stem Cell Virus Promoter Drives Correlated Transgene Expression in the Leukocytes and Cerebellar Purkinje Cells of Transgenic Mice.. This is an open-access

To investigate the mechanism of lymphoma regression, we tested whether Cre activation could induce apoptosis in a p53 2 / 2 lymphoma cell line derived from the mouse model.. Cre-ER

However, in B6 Ly49C transgenic mice where all NK cells express the inhibitory receptor, MCMV infection results in altered NK cell activation associated with increased

In addition to a role for Fyn kinase in IL-4- mediated B cell and T cell activation [38,39], we recently showed that Fyn is required for IgE-induced STAT5 activation in mast

Based on these lines of evidence, together with previous studies demonstrating that Cre-mediated recombination in cells with inverted loxP sites in the genome can cause chromosome