Peroxisome proliferator-activated receptor γ deficiency in T cells accelerates chronic rejection by influencing the differentiation of CD4+ T cells and alternatively activated macrophages.

IL-23 induces the polarization of virgin CD4 T-cells in T helper 17 cells (Th-17), which leads to the production of IL-17, a pro-in fl ammatory cytokine found at high levels in

effects of CsA and Tac on the differentiation of naı¨ve CD4 + T cells into cytokine-producing memory T cells as well as on the actual cytokine secretion from memory CD4 + T cells

The differentiation of iTreg during lymphopenia induced proliferation upon adoptive transfer to T cell deficient recipients limits the expansion of the T

Furthermore, mesenchymal stem cells promoted strong inhibition of CD4+ and CD8+ T cell proliferation, increased the frequency of CD4+CD25+Foxp3 T cells, and changed the global

marrow, T cell progenitors migrate to the thymus to develop to mature TCRalpha/beta CD4 and CD8 T cells, as well as TCRgamma/delta T cells.. During development in primary

These were characterized by a decrease in the frequency of activated effector T cell phe- notypes and of the T cell phenotype, most strictly associat- ed with Treg function (CD3 +

As a specific example, we designed an array that labels the main cell types in the mouse spleen within one tissue section (B cells, CD4 + T cells, CD8 + T cells, dendritic

We studied the expression and function of individual T cell LPA receptors in naı¨ve and activated CD4 + cells using in vitro migration assays and adoptive transfer strategies..