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Partial deletion of chromosome 8 β-defensin cluster confers sperm dysfunction and infertility in male mice.

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Academic year: 2017

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Figure 1. DefbD9/DefbD9 mice with deletion of 9 b-defensin genes. Figure 1A: Generation and gene targeting of DefbD9 mice
Figure 2. DefbD9/DefbD9 male mice are infertile. Figure 2A: Litter sizes of Defb D 9/Defb D 9 (2/2) male mice mated to wild-type CD1 females over 3 months
Figure 4. Precocious capacitation and increased spontaneous acrosome reaction in sperm from Defb D 9/Defb D 9 mice
Figure 5. Ultrastructure of spermatozoa from cauda, caput and testis from wild-type littermates (+/+) and Defb D 9/Defb D 9 ( 2 / 2 ) male mice reveals a defect in microtubule structure

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