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Linoleic acid-induced mitochondrial Ca(2+) efflux causes peroxynitrite generation and protein nitrotyrosylation.

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Academic year: 2017

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Figure 1. LA-induced [Ca 2+ ] i mobilization and ROS generation. Human mesangial cells were labeled with fura-2 (1 mM) alone or together with DCF (1 mM) (37 u C, 30 min)
Figure 2. The LA-induced ROS signal was identified as peroxynitrite. (A): HM cells were labeled with fura-2 and DCF and traces represent LA- LA-induced [Ca 2+ ] i mobilization (black trace) and ROS generation (red trace); (B): same measurements performed i
Figure 3. Mitochondria played an essential role in LA-induced [Ca 2+ ] i mobilization and peroxynitrite generation
Figure 5. The effect of hsp90b1 on LA-induced [Ca 2+ ] i
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