HIV-1 Nef enhances dendritic cell-mediated viral transmission to CD4+ T cells and promotes T-cell activation.

In this study, we used THP-1 (human monocytic leukemia cell line) as monocytic DC precursors to investigate how overexpression of HIV-1 Nef influences the processes of

Risk factors associated with sexual transmission of HIV-1 infection in healthy individuals, HIV-1 exposed but uninfected individuals, HIV-1-infected asymptomatic, and patients

Communication between immune cells involves the formation of the immunological synapse that sta- bilizes TCR engagement for the time required for gene transcrip- tion and for

To investigate the impact of sequence variations in HIV-1- derived peptides on KIR/HLA interactions and NK cell responses, we used a library of overlapping HIV-1 p24 peptides

Gummuluru S, KewalRamani VN, Emerman M (2002) Dendritic cell-mediated viral transfer to T cells is required for human immunodeficiency virus type 1 persistence in the face of rapid

(2009) Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of

(A) The infectivity of the indicated NL43 viruses produced by 293 cells in the absence or presence of 50 m M 2c was determined using TZM-bl cells as the target cells and is expressed

Effect of soluble DC-SIGN on HIV-1 infection in vitro The data reported above indicate that cis expression of DC- SIGN enhances infection with HIV-1 both by concentrating virus at