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Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology.

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Academic year: 2017

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Figure 1. Pictorial outline of methodology. A. Genes overlapping the wingspan of associated SNPs are defined, and these genes code for associated proteins
Figure 3. Candidate RA and CD genes are preferentially expressed in immune tissues. We obtained tissue expression data for 126 different cell types from a publicly available database, which was grouped into immune, gastrointestinal (GI), neuronal and ‘othe
Table 1. RA and CD candidate genes are preferentially expressed in immune tissues.
Figure 4. Final disease networks. Resultant networks built from candidate genes are depicted for RA and CD (A and B, respectively)

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