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Transcriptional and epigenetic regulation of KIF14 overexpression in ovarian cancer.

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Academic year: 2017

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Figure 1. KIF14 promoter activity. Promoter deletion constructs fused to Luciferase were tested for activity in HeLa, SKOV3 and OvCa429 cells.
Figure 2. Knockdown of endogenous SP1 and YY1 mRNA inhibits KIF14 transcription. siRNA knockdown of endogenous Sp1 (orange), HSF1 (green), and YY1 (red) transcription factors, and measurement of their mRNA expression along with corresponding KIF14 mRNA lev
Table 1. Pearson correlation between KIF14 gain/no gain tumors and Sp1, HSF1 and YY1 mRNA.
Figure 8. Candidate miRNAs modulate KIF14 mRNA expression in an OvCa cell line. SKOV3 cells were treated with either candidate miRNA mimics that increased miRNA expression 200–6000-fold, or miRNA inhibitors that decreased expression by 70–100%

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