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Metabolic constraint-based refinement of transcriptional regulatory networks.

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Academic year: 2017

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Figure 1. Process of identifying phenotype-consistent interactions using GEMINI. A. High-throughput interaction data were mapped onto a biochemically detailed metabolic network using PROM and phenotypic consequences of these interactions were predicted
Figure 2. Refining regulatory interaction data in yeast using GEMINI. A. GEMINI was evaluated for its ability to preferentially retain the gold- gold-standard interactions (blue edges) and the indirect interactions (green edges)
Figure 3. Iterative approach for network refinement and phenotype prediction. By using an iterative approach, we increased the comprehensiveness of the integrated network model by adding new interactions (Network III) and iteratively refining the model usi

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