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3-Hydroxy-quinolin-2(1H)-ones, a useful scaffold : synthesis and biological evaluation

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Figure 1.1 – Number of publications referring quinolin -2(1H)-ones since 1982, according to Web  of Science and using “Quinolin -2(1H)-ones” as keyword
Figure 1.2 – Putative binding mode of amide 42 in the RT RNase H catalytic site. 72
Figure 1.4 – Characteristic pKa values of carboxylic acid, benzoic acid 48 and 3HQ 9.
Figure 1.6 – Schematic representation of bonding interactions of compound 9 with those of  carboxylic acids inhibitors (benzoic acid)
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