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Effect of angiotensin-(1-7) on reperfusion arrhythmias in isolated rat hearts

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Academic year: 2019

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Figure 1 shows the percentage of change in contraction force, heart rate and coronary flow in isolated hearts perfused with normal Ringer solution or normal  Krebs-Ringer solution containing different  concen-trations of Ang-(1-7) and Ang II
Figure 2 - Coronary flow (upper), contraction force (middle) and  di-astolic tension (lower) in isolated rat hearts perfused with  Krebs-Ringer solution (control, N = 11), Krebs-Ringer solution containing 27 nM Ang-(1-7) (N = 8) or  Krebs-Ringer solution c
Figure 4). On the other hand, a tendency to an increased ASI was observed in Ang  II-perfused hearts (8.00 ± 1.84  vs  6.64 ± 1.29 for the control group, P>0.05; Figure 4)
Figure 4 - Averaged arrhythmia severity index (upper panel) and percentage of irreversible  ar-rhythmias (more than 30 min) (lower panel) upon reperfusion after 15 min of occlusion of the left anterior descending  coro-nary artery in isolated rat hearts pe

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