• Nenhum resultado encontrado

Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclasts.

N/A
N/A
Protected

Academic year: 2017

Share "Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclasts."

Copied!
11
0
0

Texto

Loading

Imagem

Figure 1. CD68 is expressed by macrophages and osteoclasts. (A) CD68 and b-actin expression in mouse bone marrow suspension cells treated with 44 ng/mL M-CSF +/2 100 ng/mL RANKL for indicated days (d)
Table 1. Mouse Birth Ratios.
Figure 6. CD68 is not expressed by osteoblasts. CD68 and b-actin expression in mouse BMMs(MQ) cultured with 220 ng/mL M-CSF and cultured mouse calvarial osteoblasts (OB) was determined by Western immunoblotting
Figure 7. CD68 2/2 osteoclasts do not efficiently resorb bone. BMMs from CD68 +/+ , +/2 , and 2/2 mice were seeded onto bovine cortical bone slices and differentiated into osteoclasts over 4 days

Referências

Documentos relacionados

The bone structural analysis of rats in the test arm group showed a significant increase in the bone volume per tissue volume (BV/TV), trabecular thickness (Tb.Th) and trabecular

The increase in bone resorption indicated by increased CTX levels accompanied a 31% lower trabecular bone volume (BV/TV) in the GnRH-a groups compared to control immediately

Contrarily, a significant increase in both bone for- mation and resorption, resulting in a decreased bone volume, were detected by histomorphological analysis applied to the

Paget’s disease of bone is a focal disorder of bone remodeling accom- panied initially by an increase in bone resorption, followed by a disorga- nized and excessive formation of

Results: In the LEV monotherapy group, the bone formation markers showed a significant decrease in serum alkaline phosphatase and serum osteocalcin levels while the bone

Osteoporosis is a disease characterized by low bone mass associated with the deterioration of microarchitecture, due to an imbalance either in high bone resorption or low

It was hypothesized that the simvastatin inhibits the relapse of tooth movement in rats, through inhibition of bone resorption (and the increase in bone formation)

Dos construtores das consciências, das catedrais e dos castelos, próprios das épocas mais antigas, a Europa passou para as construções arrojadas ontem apenas sonhadas, hoje talvez