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Retinal pigment epithelium degeneration caused by aggregation of PRPF31 and the role of HSP70 family of proteins

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Fig. 1 Prpf31 A216P/+ mice exhibit degenerative phenotype of the RPE with drusen-like deposits
Figure S3) showed that protein level is comparatively higher in the RPE than in the rest of the retinal layers in several vertebrates, including humans.
Fig. 3 Large cytoplasmic aggregates of Prpf31 protein were observed in the RPE of Prpf31 A216P/+ mice
Table 1 Summary of gene level differential expression analysis in RPE samples in two different conditions ( Prpf31 A216P/+ vs WT mice).
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