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Supervisor: Rui Manuel Freitas Oliveira, Associate Professor, FCTUNL Co-supervisor: Nuno Eduardo Buxo Carinhas, PhD, iBET

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Academic year: 2019

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Figure 1.1  –  Geometric interpretation of a metabolic network analysis. (a) All possible flux  distributions  of  a  metabolic  network  lie  within  the  admissible  flux  cone
Figure  2.1  -  Metabolic  network  of  CHO  cells  (adapted  from  [29]).  Nucleotide  synthesis,  lipid  synthesis,  IgG  glycosylation  and  transport  reactions  were  omitted
Table 2.1 - Composition of serum-free medium CHO-T1-SF [37].
Figure  3.1  –   Heat  map  of  all  EFMs  initially  obtained  (normalized  data).  Metabolites  in  green are consumed and in red are produced
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