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Context-dependent roles for lymphotoxin-beta receptor signaling in cancer development

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Academic year: 2021

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Figure  1.  LTβR,  lymphotoxin  and  LIGHT  proteins  and  genes.  A) Genomic localization  and  exon-intron  structure  of  LTBR,  LTA,  LTB,  and  TNFSF14/LIGHT  human  genes
Figure  2.  LTβR-mediated  signal  transduction  pathways  leading  to  target  gene  expression  and  cell  death
Figure 3. LTβR anti-oncogenic roles. Activation of LTβR signaling leads to anti-oncogenic  effects  due  to  three  main  mechanisms
Figure 4. LTβR pro-oncogenic roles.  Activation of LTβR signaling favors oncogenesis due  to  four  main  mechanisms

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