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Arq Bras Endocrinol Metab vol.53 número8

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Figure 1. IGF-I and insulin receptor activation and downstream signaling.
Table 1. Meta-analyses evaluating IGF-I and IGFBP-3 levels (comparison of highest and lowest quantiles) and prostate cancer risk
Figure 2. Therapeutic strategies targeting the IGF-I - IGF-IR signaling.
Figure 3. Metformin actions that may be important for prostate cancer treatment  AMPK: AMP-activated protein kinase; IRS: insulin-receptor substrate; TOR: target of rapamycin; S6K:

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