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Network analyses reveal pervasive functional regulation between proteases in the human protease web.

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Academic year: 2017

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Figure 1. Biochemical protease interactions represented by graph theory. Proteases influence cleavage of substrates both directly and also indirectly through cleavage of other proteases and inhibitors
Figure 3 shows that our network data from MEROPS/
Figure 6B shows liver, spleen, and skin results in more detail.
Figure 3. The largest connected component of the human protease web. The structure of the core of the human protease web is comprised of 255 connected proteases and inhibitors that form the largest connected component
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