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REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I.

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Academic year: 2017

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Figure 2. REUL associates with RIG-I. (A) REUL interacts with RIG-I but not MDA5 and VISA
Figure 3. REUL potentiates RIG-I signaling. (A), (B), (C) REUL potentiates RIG-I-, but not MDA5-mediated activation of ISRE (A), NF-kB (B) and IFN- IFN-b (C) promoter in a dose-dependent manner
Figure 4. REUL potentiates RIG-I antiviral activity. (A), (B), (C) RING domain deletion mutant REULDRING suppresses SV-induced activation of ISRE (A), NF-kB (B) and IFN-b (C) promoter in a dose-dependent manner
Figure 5. REUL is an E3 ubiquitin ligase of RIG-I. (A) REUL increases the ubiquitination levels of RIG-I in overexpression system
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