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Design, synthesis and evaluation of xanthone derivatives for dual activity: antitumor and P-glycoprotein inhibition

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Academic year: 2019

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Figure 1. Cellular factors that cause drug resistance (adapted 3 )
Figure  2.  Predicted  membrane  topology  for  the  human  ABC  transporters  P-gp,  MRP1-8  and  BCRP
Figure 3. Schematic representation of P-gp structure with TMD 1 (TM1 to TM6) and TMD 2 (TM7  to TM12), and with the two ATP-binding sites (NBD1 and NBD2) (adapted 44 )
Figure 4. Binding cavity in the inward-facing conformation of an homology model of human P-gp:
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