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Human REV3 DNA Polymerase Zeta Localizes to Mitochondria and Protects the Mitochondrial Genome.

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Academic year: 2017

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Fig 1. Human REV3L contains a mitochondrial localization signal (MLS) and localizes to mitochondria
Fig 2. Rev3 inactivation affects mitochondrial functions. (A) Western blot analysis of representative subunits of mitochondrial respiratory complexes I-V in Rev3 +/+ and Rev3 -/- mouse embryonic fibroblasts
Fig 3. Inhibition of OXPHOS increases REV3 expression. (A) RT PCR analysis of Rev3 gene expression in 143B parental and rho° cells
Fig 4. REV3 protects cells from mtDNA damage. (A) RT PCR results showing a time-dependent increase in Rev3 gene expression in Rev3 +/+ cells after UV exposure
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