Efeitos do exercício físico e do polimorfismo I/D do gene da ECA sobre a resposta da pressão arterial e N02

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Universidade

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Católica de Brasília

Pró-Reitoria de Pós-Graduação e Pesquisa

Programa de Pós-Graduação Stricto Sensu em Educação Física

EFEITOS DO EXERCíCIO FíSICO E DO POLIMORFISMO I/O

DO GENE DA ECA SOBRE A RESPOSTA DA PRESSÃO

ARTERIAL E N0

2-Autor: Marcelo Pereira Magalhães de Sales

Orientador: Prof. Or. Herbert Gustavo Simões

Brasília - DF

EFEITOS DO EXERCíCIO FÍSICO E DO POLIMORFISMO IID DO GENE DA ECA SOBRE A RESPOSTA DA PRESSÃO ARTERIAL E N0

2-Dissertação apresentada ao Programa de Pós-Graduação Stricto Sensu em Educação Física da

Universidade Católica de Brasília (UCB), como parte dos requisitos para a obtenção do título de Mestre em Educação Física.

Orientador: Prof. Dr. Herbert Gustavo Simões

12,5 cm

7,5 cm 7,5cm

Ficha elaborada pela Biblioteca Pós-Graduação da UCB 10/12/2012

S163e Sales, Marcelo Pereira Magalhães de.

Efeitos do exercício físico e do polimorfismo I/D do gene da ECA sobre a resposta da pressão arterial e NO2. / Marcelo Pereira Magalhães de Sales – 2012.

99f. ; il.: 30 cm

Dissertação (mestrado) – Universidade Católica de Brasília, 2012. Orientação: Prof. Dr. Herbert Gustavo Simões

1. Exercícios físicos. 2. Pressão arterial. 3. Diabetes. 4. Idosos. I. Simões, Herbert Gustavo, orient. II. Título.

Católica de Brasília

Dissertação de autoria de Marcelo Pereira Magalhães, intitulada: "EFEITOS

DO EXERCíCIO FíSICO E DO POLIMORFISMO l/O E DO GENE DA ECA SOBRE A RESPOSTA DA PRESSÃO ARTERIAL E N02 " apresentada, como requisito parcial para obtenção do grau de Mestre em Educação Física da Universidade

Católica de Brasllia, em 23 de fevereiro de 2012, defendida e aprovada pela banca examinadora abaixo assinada:

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Praf. Dr. Herbert Gustavo Simões

Orientador

Universidade Católica de Brasília - UCB

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_{Grubert Campbell}

Universidade Católica de Brasilia - UCB

Agradeço primeiramente a Deus por permitir minha vinda a este mundo e poder compartilhar do convívio de todas as pessoas que ele colocou em meu caminho. Obrigado Senhor.

Agradeço aos meus pais, que por ser abençoado por Deus, ganhei muitos, pois minha "Vovó" Maria Sales, que fez o que pode pra me oferecer uma vida melhor, se sacrificou, e por diversas ocasiões abriu mão da própria vida pra se dedicar quase que exclusivamente a mim. Obrigado VÓ. Aos meus tios Isarael Sales, Joel Sales. A minha "titia" Noêmia Sales, que desde muito jovem precisou amadurecer, precisou ser minha mãe, e o fez com muita competência e dedicação, obrigado tia. Agradeço também as minhas tias Geny Sales, Marlene Sales, Miriam Sales e Laudicéia Sales, que todas entre si revesaram em meus cuidados, renunciando suas juventudes para se dedicarem a mim. Obrigado tias, perdoe por ter "roubado" essa etapa de vossas vidas, serei sempre grato.

Agradeço minha mãe Cristina Magalhães, pelo incentivo de sempre. Aos meus irmãos Júnior, Jaqueline, Samara, Cristiano e Gabi. Ao meu pai Samuel Sales, que com bons exemplos de conduta me fez um homem melhor do que um dia poderia ser.

Um agradecimento especial a minha noiva e em breve esposa Lucília Rodruigues "minha bichinha", pois esteve comigo em períodos difíceis e de poucas perspectivas de melhora, tendo mais fé em mim do que eu mesmo em alguns momentos e por me suportar durante esses 10 anos. Amo você, minha bichinha.

A minha sogra "Dona Marlene", que por muitas vezes durante minha graduação em momentos de dificuldades, financiou parte dos meus estudos e como minha noiva, confiou e acreditou em mim e por muitas vezes se fez minha mãe.

Aos meus orientadores e amigos, Professor Dr. Herbert Gustavo Simões e Carmen Sílvia Grubert Campbell, especialmente por sempre me oportunizarem e também pelos ensinamentos extra-acadêmicos.

"Benfa", Daniele Garcia "desenrolada", Rafael Cunha "Rafilsks", Guilherme Magalhães "moranguinho", Edilberto Barros "coroa", Aparecido Pimentel "Cidão", Júnior Wagner "man", Luís Carlos "louco", José Fernando ''Tcheba'', Wilson Botelho "psico" João Maurício "carranca", Ll1ian "superman" e Patrícia Marques "Paty". Ao meu mestre de Jiu-Jitsu José Luís e companheiros de equipe. Aos membros da banca, professor Dr. Otávio, amigo de longa data e importante colaborador e ao Professor Dr. Fábio, pelo suporte, paciência e disponibilidade. E a todos aqueles que de alguma forma contribuíram para este acontecimento.

Referência: SALES, Marcelo Pereira Magalhães de. Efeitos do exerClClO fisico e do polimorfismo IID do gene da eca sobre a resposta da pressão arterial e NOz-. 100 páginas. Mestrado em Educação Física - Universidade Católica de Brasília, Brasília, 2012.

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presente documento intitulado: efeitos do exercício físico e do polimorfismo IID do gene da ECA sobre a pressão arterial e N02- pós-exercício reúne cinco artigos, sendo quatro publicados, e um aceito para publicação em periódicos científicos, cujo conhecimento apresentado, compõe esta dissertação de Mestrado em Educação Física da Universidade Católica de Brasília. Os artigos apresentam informações a respeito da determinação do limiar de lactato e ventilatório a partir da variabilidade da frequência cardíaca em indivíduos diabéticos tipo 2 (DM2), sendo esta população amplamente acometida de disfunção autonômica. Além disso, a partir dos dados relativos às cargas de limiar de lactato e ventilatório, foram elaborados modelos de intervenção para o controle da pressão arterial na população diabética (dibetes tipo 2) e idosa, sendo que estas populações apresentam um alto índice de prevalência de hipertensão arterial sistêmica (HAS). Estudo 1: O limiar de variabilidade da frequência cardíaca (LVFC) pode ser identificado a partir de 2 critérios: (1)

realização do exercício. Estudo 5: Por outro lado, evidências sugerem que não somente a intensidade do exercício pode interferir na resposta da PA e do NO, variações genéticas parecem exercer um importante papel no controle de mecanismos de regulação da PA. Dessa forma, o presente estudo também investigou o efeito da intensidade do exercício (teste incremental máximo e exercício realizado com carga relativa a 90% do limiar anaeróbio) e do polimorfismo IID do gene da ECA, sobre as resposta de PA e NO no período pós-exercício. Os resultados apontam que não somente a intensidade do exercício interfere na resposta da PA no período pós-exercício, mas também que o alelo (I ou D) que compõe os genótipos (11, ID e DD) pode interferir nessa resposta, uma vez que, somente aqueles indivíduos que apresentam genótipos 11 e ID mostraram aumento na liberação de NO e também apresentaram HPE de maior magnitude.

may interfere in this response, since only those individuais who 11 and ID genotypes showed increased release of NO as well as greater magnitude of post exercise hypotension.

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